Intravenous ondansetron reduced nausea but not pruritus following intrathecal morphine in children

Interim results of a randomized, double‐blinded, placebo‐control trial

Pediatric Anesthesia

Reviewed July 2023 by Dr Falk Reinholz

Study Design - Prospective, double-blinded, randomized, placebo-controlled trial. Single centre in USA where intrathecal morphine (ITM) is commonly utilised. - Ondansetron 0.1mg/kg (max 16mg) or...

Safety of Intrathecal Clonidine as an Adjuvant to Spinal Anesthesia in Infants and Children

Pediatric Anesthesia

Reviewed September 2025 by Dr David Roche

This retrospective chart review explores the safety of intrathecal clonidine in infants and children up to 3 years of age who received spinal anaesthesia. Methods In this single centre study the...

A Randomized Controlled Trial of Intrathecal versus Caudal Morphine-Bupivacaine on Postoperative Analgesia and Cortisol Levels in Pediatric Patients

Bupivacaine on Postoperative Analgesia and Cortisol Levels in Pediatric Patients

Anesthesia Analgesia

Reviewed September 2025 by Dr Stephanie Pauling

This study compared the analgesic outcomes of caudal morphine and bupivacaine with intrathecal morphine and bupivacaine in patients aged 1-5 having general, urological and orthopaedic surgery below...