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Anesthesia and neurodevelopment after 20 years

Where are we now and where to next?

Anaesthesia

Reviewed June 2023 by Dr Shona Chung

This extensive editorial starts with the history of research into neurodevelopmental effects of general anaesthesia in children: from the initial study in rats in 2003 to the FDA black box warning in...

Anesthesia and Sedation Exposure and Neurodevelopmental Outcomes in Infants Undergoing Congenital Cardiac Surgery

A Retrospective Cohort Study

Anesthesiology

Reviewed December 2023 by Dr Rebecca McIntyre

The authors of this retrospective study hypothesized that greater exposure to sedation and anaesthesia in children undergoing complex cardiac surgery is associated with lower neurodevelopmental...

Exposure to Operative Anesthesia in Childhood and Subsequent Neurobehavioral Diagnoses

A Natural Experiment Using Appendectomy

Anesthesiology

Reviewed November 2024 by Dr Eamonn Upperton

Overview: This retrospective study looks at the risk of developing a neurobehavioural diagnosis in two parallel groups of children aged between 3 and 15 years: - Those who underwent...

Long-term outcomes of early exposure to repeated general anaesthesia in children with cystic fibrosis (CF-GAIN)

A multicentre, open-label, randomised controlled phase 4 trial

The Lancet

Reviewed February 2025 by Dr Nicole Wylie

Summary - Study Type: The initial trial was a prospective, open-label, unblinded, randomised and multi-centre trial designed to look at the entirely different clinical question of pulmonary and...

Short-term Outcomes in Infants after General Anesthesia with Low-dose Sevoflurane/Dexmedetomidine/Remifentanil versus Standard-dose Sevoflurane

The TREX Trial

Anesthesiology

Reviewed March 2025 by Dr Roeland Passier

Summary This is a secondary analysis comparing the two treatment groups in The Trial Remifentanil DEXmedetomidine (TREX) trial looking at early perioperative results. TREX, which is ongoing, was...

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