Effects of Dexmedetomidine-Remifentanil on Neurodevelopment of Children after Inhalation Anesthesia
A Randomized Clinical Trial.
Anesthesiology
Reviewed January 2026 by Dr Andrew Hughes
This prospective, double-blind RCT compares the neurodevelopmental effect of a single GA exposure using different doses of sevoflurane in children under 2 years of age. Children were randomised to...
The Influence of Electroencephalographic Density Spectral Array Guidance of Sevoflurane Administration on Recovery From General Anesthesia in Children. A Randomized Controlled Trial
Pediatric Anesthesia
Reviewed July 2025 by Dr Sharon Eow
Single centre, prospective randomised controlled trial conducted at Sophia Children’s Hospital, a tertiary paediatric hospital in Rotterdam, Netherlands, between September 2022 and March 2024 ...
Electroencephalography and Anesthetic Depth in Children Under 2 Years of Age
A Prospective Observational Study
Pediatric Anesthesia
Reviewed July 2025 by Dr Grace Andrews
This single-centre prospective observational study aimed to compare EEG spectral parameters during periods of false positive elevations in processed EEG indices to elevations in these indices during...
Short-term Outcomes in Infants after General Anesthesia with Low-dose Sevoflurane/Dexmedetomidine/Remifentanil versus Standard-dose Sevoflurane
The TREX Trial
Anesthesiology
Reviewed March 2025 by Dr Roeland Passier
This is a secondary analysis comparing the two treatment groups in The Trial Remifentanil DEXmedetomidine (TREX) trial looking at early perioperative results. TREX, which is ongoing, was designed to...
Consensus on decommissioning piped nitrous oxide from UK and Ireland operating theatre suites
A rational approach to an increasingly ignoble gas
Anaesthesia
Reviewed March 2025 by Dr Louisa Swain
This editorial summarises the context and evidence for the release of the July 2024 Consensus statement of the Association of Anaesthetists, Royal College of Anaesthetists, College of...
Comparison of postoperative pain in children after maintenance anaesthesia with propofol or sevoflurane
A systematic review and meta-analysis
British Journal of Anaesthesia
Reviewed August 2024 by Dr Rory Walsh
This was a systematic review and meta-analysis of 13 randomised controlled trials that compared post-operative pain between sevoflurane and propofol anaesthesia in children. The primary outcome was...
Effect of BIS-guided anesthesia on emergence delirium following general anesthesia in children
A prospective randomized controlled trial
Anaesthesia Critical Care & Pain Medicine
Reviewed February 2024 by Dr Priya Sreedharan
This prospective, randomised, double-blinded study was conducted at the University hospital of Ostrava in the Czech Republic. The study hypothesized that optimizing the depth of general anaesthesia...
It's time to stop using nitrous oxide for pediatric mask induction
Pediatric Anesthesia
Reviewed June 2024 by Dr Andrew Chazan
This short ‘perspectives essay’ is aimed at getting anaesthetists to reconsider the routine use of nitrous oxide in mask induction of anaesthesia. The points raised in the article include: Greater...
The role of volatile capture technology in desflurane disposal from decommissioned vaporisers
Anaesthesia
Reviewed December 2023 by Dr Rebecca McIntyre
This letter outlines a pilot project examining a method for capturing retained desflurane from decommissioned desflurane vaporizers in the UK. As part of the NHS’s drive to be more environmentally...
Reducing the environmental impact of mask inductions in children
A quality improvement report
Pediatric Anesthesia
Reviewed December 2023 by Dr Tracy Jackson
The environmental impact of anaesthetic gases are of increasing concern. In Australia and New Zealand, children are traditionally induced by gas induction with high flow nitrous/oxygen and...
Comparison of intravenous and inhalation anesthesia on postoperative behavior changes in children undergoing ambulatory endoscopic procedures
A randomized clinical trial
Pediatric Anesthesia
Reviewed March 2023 by Dr Priya Sreedharan
This randomized, parallel, double-blinded clinical trial performed in an outpatient endoscopic clinic between October 2018 and December 2021 was designed to determine if intravenous anaesthesia was...
Dexmedetomidine Diminishes, but Does Not Prevent, Developmental Effects of Sevoflurane in Neonatal Rats
Anesthesia Analgesia
Reviewed September 2022 by Dr Suze Bruins
An animal study (rats), investigating whether pre-treatment with dexmedetomidine (DEX) can reduce sevoflurane-induced neuronal hyperexcitation and corticosterone release at the time of exposure, as...
Respiratory Adverse Events After LMA® Mask Removal in Children
A Randomized Trial Comparing Propofol to Sevoflurane
Anesthesia Analgesia
Reviewed January 2023 by Dr Justin Skowno
This RCT in 134 low risk children having general anaesthesia with an LMA were randomized between propofol and sevoflurane anaesthesia, with fentanyl analgesia, awake LMA removal and other clinical...
