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6 foundTip: use year and tags above to explore the back catalogue without typing a specific article name.
Effects of Dexmedetomidine-Remifentanil on Neurodevelopment of Children after Inhalation Anesthesia
A Randomized Clinical Trial.
Anesthesiology
January 2026 by Dr Andrew Hughes
This prospective, double-blind RCT compares the neurodevelopmental effect of a single GA exposure using different doses of sevoflurane in children under 2 years of age. Children were randomised to...
Short-term Outcomes in Infants after General Anesthesia with Low-dose Sevoflurane/Dexmedetomidine/Remifentanil versus Standard-dose Sevoflurane
The TREX Trial
Anesthesiology
March 2025 by Dr Roeland Passier
This is a secondary analysis comparing the two treatment groups in The Trial Remifentanil DEXmedetomidine (TREX) trial looking at early perioperative results. TREX, which is ongoing, was designed to...
Long-term outcomes of early exposure to repeated general anaesthesia in children with cystic fibrosis (CF-GAIN)
A multicentre, open-label, randomised controlled phase 4 trial
The Lancet
February 2025 by Dr Nicole Wylie
The initial trial was a prospective, open-label, unblinded, randomised and multi-centre trial designed to look at the entirely different clinical question of pulmonary and nutritional outcomes. This...
Exposure to Operative Anesthesia in Childhood and Subsequent Neurobehavioral Diagnoses
A Natural Experiment Using Appendectomy
Anesthesiology
November 2024 by Dr Eamonn Upperton
This retrospective study looks at the risk of developing a neurobehavioural diagnosis in two parallel groups of children aged between 3 and 15 years: Those who underwent appendicectomy Those...
Anesthesia and Sedation Exposure and Neurodevelopmental Outcomes in Infants Undergoing Congenital Cardiac Surgery
A Retrospective Cohort Study
Anesthesiology
December 2023 by Dr Rebecca McIntyre
The authors of this retrospective study hypothesized that greater exposure to sedation and anaesthesia in children undergoing complex cardiac surgery is associated with lower neurodevelopmental...
Anesthesia and neurodevelopment after 20 years
Where are we now and where to next?
Anaesthesia
January 2023 by Dr Shona Chung
This extensive editorial starts with the history of research into neurodevelopmental effects of general anaesthesia in children: from the initial study in rats in 2003 to the FDA black box warning in...
